2M.D., Rod EL Farag Eye World Hospital, National Eye Center, Dokki-Giza/ EGYPT
3M.D., Ain Shams University Faculty of Medicine, Department of Ophthalmology, Cairo/EGYPT Purpose: Threshold zone 1 and 2 ROP is a progressive disease with vision threatening complications. In this cohort, we could achieve retinal stabilization when 0.625mg/ 0.05 ml injection was performed 3-4 days prior to retinal ablation.
Material and Methods: Fourteen eyes received intravitreal bevacizumab. Inclusion criteria was zone 1,2 disease, stage 3, or 4 disease with plus disease. Four days later, laser PRP was given in a scatter pattern to the retinal periphery. Mean gestational age was 30 weeks, mean birth weight was 1279 gms, mean incubation period was 36 days and oxygen delivery for 15 days.
Results: 11 eyes achieved retinal stabilization. Three eyes progressed to progressive tractional retinal detachment. One eye was successfully reposited by lens-sparing vitrectomy, one eye failed surgery and one eye was not operated. No systemic toxicity was observed from bevacizumab injection.
Conclusions: Bevacizumab 0.625 mg / 0.05 ml is a useful adjunct in posterior zone 1,2 ROP when followed by scatter laser photocoagulation.
Keywords : Intravitreal bevacizumab, laser photokoagulasyon, retinopathy of prematurity