2Asist. Dr., Ankara Atatürk Eğitim ve Araştırma Hastanesi, Yıldırım Beyazıt Üniversitesi, Göz Kliniği, Ankara - TÜRKİYE
3Doç. Dr., Ankara Atatürk Eğitim ve Araştırma Hastanesi, Yıldırım Beyazıt Üniversitesi, Göz Kliniği, Ankara - TÜRKİYE Aim: To compare the effect of short term intraocular pressure (IOP) change after low-dose intravitreal triamcinolone acetonid (IVTA) injection and sustained-release dexamethasone (DEX) implantation in cases with persistent diabetic macular edema (DME).
Materials and Methods: In this study, 59 eyes of 59 patients, who received intravitreal corticosteroids due to persistent DME were analyzed retrospectively. Group 1 was consisted of 27 eyes with IVTA injection (2 mg/0.05 ml) and group 2 had 32 eyes with DEX implantation (0.7 mg). IOP, best corrected visual acuity (BCVA) and central macular thickness (CMT) were evaluated before injection and at the 1st and 3rd months after injection.
Results: The mean baseline, 1st and 3rd month IOP measurements were 14.6 ± 3.1, 16.1 ± 3.2 and 17.8 ± 4.8 mmHg in group 1, 15.1 ± 2.2, 17.6 ± 4.8 and 18.3 ± 4.2 mm Hg in group 2, respectively. Baseline, 1st and 3rd month IOP measurements were not signifi cantly different between groups (p>0.05). At the end of 3rd month follow-up, steroid induced ocular hypertension (OHT) was observed in 7 cases (%25) in group 1 and 9 cases (%30) in group 2. In each group, the improvement of BCVA and CMT from baseline were statistically significant at the 1st and 3rd months follow-up (p=0.001 for each).
Conclusions: Intravitreal corticosteroid injection was an effective treatment method in the treatment of persistent DME. After low-dose IVTA injection and DEX implantation, the change in IOP levels were similar in the short term follow-up.
Keywords : Triamcinolone acetonid, dexamethasone implant, diabetic macular edema, steroid induced ocular hypertension