2Uz. Dr., Çivril Devlet Hastanesi, Göz Hastalıkları, Denizli, Türkiye
3Uz. Dr., Tunceli Devlet Hastanesi, Göz Hastalıkları, Tunceli, Türkiye
4Uz. Dr., Bozyaka Eğitim ve Araştırma Hastanesi, Göz Hastalıkları, İzmir, Türkiye
5Uz. Dr., Van Eğitim ve Araştırma Hastanesi, Göz Hastalıkları, Van, Türkiye
6Uz. Dr., Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eğitim ve Araştırma Hastanesi, Göz Hastalıkları, Ankara, Türkiye
7Asist. Dr., Dokuz Eylül Üniversitesi Tıp Fakültesi Hastanesi, Göz Hastalıkları, İzmir, Türkiye
8Yrd. Doç. Dr., Dokuz Eylül Üniversitesi Tıp Fakültesi Hastanesi, Göz Hastalıkları, İzmir, Türkiye
9Uz. Dr., Dokuz Eylül Üniversitesi Tıp Fakültesi Hastanesi, Göz Hastalıkları, İzmir, Türkiye
10Prof. Dr., Dokuz Eylül Üniversitesi Tıp Fakültesi Hastanesi, Göz Hastalıkları, İzmir, Türkiye Purpose: To compare macular photoreceptor(PR) , retina pigment epithelium(RPE) and choroidal thickness by enhanced depth optic coherence tomography(EDI-OCT) in healthy subjects with positive family history for age related macular degeneraton(AMD) in first degree relative and control subjects.
Materials and Methods: 106 eyes of 53 healty subjects with positive family history for moderate or advanced stage dry or wet type AMD in one of their parents(group 1) and 166 eyes of 83 age matched control subjects(group 2) were included to study. All subjects underwent a comprehensive ophthalmologic examination. PR, RPE and choroidal thickness measurements were taken at fovea, at 500 ?m, 1000 ?m and 2000 ?m nasal or temporal to the fovea center by EDI-OCT(Heidelberg Engineering, Germany).
Results: There was no signifi cant difference between two groups according to age, sex, axial length and introocular pressure (p>0.05). Mean PR thickness was signifi cantly thinner in group 1 than group 2 except at 2000 ?m temporal to the fovea (p=0.132 for 2000 ?m temporal to the fovea, p<0.05). Mean RPE thickness was signifi cantly thinner in group 1 than group 2 except at 500 ?m nasal to the fovea (p=0.450 nazal 500 ?m, p<0.05). Mean choroidal thickness was significantly thinner in group 1 than group 2 at all locations (p<0.05)
Conclusion: PR, RPE and choroidal thinning may occur in healthy subjects with positive family history for AMD in first degree relative before AMD signs are seen. So further studies are needed to evaluate if healthy subjects with positive family history for AMD tend to be AMD..
Keywords : Choroidal thickness, optic coherence tomography, age related macular degeneration