2Yrd. Doç. Dr., Ahi Evran Üniversitesi Tıp Fakültesi Nöroloji ABD, Kırşehir, Türkiye Purpose: We aimed to measure lamina cribrosa thickness (LCT), lamina cribrosa depth (LCD) and retinal nerve fi ber layer (RNFL) thickness in multiple sclerosis (MS) patients and compare the results with eyes of healthy subjects.
Materials and Methods: The eyes of multiple sclerosis patients were compared with the eyes of a healthy control group. A full ophthalmologic examination was conducted for both groups. Optic coherence tomography (OCT) was used to measure LCT, LCD, and RNFL thickness values. Correlation analysis was conducted between the Expanded Disability Status Scale (EDSS) score and disease duration of the MS patients and the LCT, LCD, and RNFL thicknesses.
Results: Mean LCT values were 171.86±62.81 ?m in the MS group and 230.1±66.84 ?m in the control group. LCT was statistically signifi cantly lower in the MS group than the control group (p<0.001). Mean LCD value was 300.9±100.5 ?m in the MS group and 279.68±99.78 ?m in the control group with no statistically signifi cant difference (p?0.05). Mean RNFL thickness was 96 ?m in MS group and 100 ?m in the control group and was statistically signifi cantly lower in the MS group (p<0.05). A statistically signifi cantly moderate relationship was found between disease duration and EDSS score in the MS group with Spearman correlation analysis (r=0.468, p<0.01). A statistically signifi cantly moderate relationship was found between the RNFL thickness and both disease duration and EDSS score (r=-0.574, r=-0.601, respectively, p<0.001).
Conclusion: The intraocular nerve fi ber layer was affected in multiple sclerosis patients. The LCT and RNFL thickness were thinner in MS patients than in the control group but there was no difference in terms of LCD values.
Keywords : Multiple Sclerosis, Lamina Cribrosa Thickness, RNFL, Optic Neuritis, LCD