2Associate Prof. MD,Kayseri Training and Research Hospital,Ophthalmology Department, Kayseri, Turkey DOI : 10.37845/ret.vit.2020.29.10 Purpose: To determine whether the disorganization of retinal inner layers (DRIL) on spectral-domain (SD) OCT is associated with visual outcomes in eyes with treatment-naive branch retinal vein occlusion (BRVO).
Materials and Methods: Thirty-two eyes of 32 treatment-naive patients with macular edema (ME) due to BRVO receiving three initial consecutive monthly intravitreal ranibizumab were enrolled in this study. SD-OCT images from baseline, 3rd-month, 6th-month visits were observed and the presence and extent of DRIL was examined in the central 1-mm-wide foveal area. The efficacy of the ranibizumab treatment, assessed by best-corrected visual acuity (BCVA), was evaluated at baseline, 3-month and 6-month visits.
Results: A total of 32 eyes were included and DRIL was present in 14 (43.7%) eyes at baseline and 9 eyes (28.1%) at 6th month (P:0.01). Baseline DRIL was found to be associated with lower baseline BCVA (0.46 LogMAR for without DRIL vs. 0.65 LogMAR for DRIL, P: 0.013) and higher central retinal thickness (405.7 vs. 442.8, P: 0.016). Decrease in DRIL intensity at 3-month follow-up was associated with increased visual acuity (VA) at 6 months (P:0.001) and baseline DRIL extent was a predictive parameter for 6 months improvement in VA (p:0.01). Sixmonth DRIL change was related to 6-month VA improvement (Pearson?s correlation test, r=0.726, P<0.001).
Conclusion: In the present study, it was observed that the improvement of BCVA was found to be related to the decrease of the DRIL intensity. Therefore, the presence of DRIL at baseline and extent of DRIL following treatment might serve as a potential SD-OCT biomarker for patients with ME secondary to treatment-naive-BRVO.
Keywords : Branch Retinal Vein Occlusion; Disorganization of Retinal Inner Layers; Optical Coherence Tomography; Ranibizumab