2Asst. Prof., MD, Department of Ophthalmology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye DOI : 10.37845/ret.vit.2024.33.16 Purpose: The aim of this study is to detect changes in retinal layers in Retinitis pigmentosa. In this way, it was thought that it could guide researchers in the process of RP treatment development.
Materials and Methods: Twenty-seven RP subjects with preserved foveal anatomy without cystoid macular edema and the same number of healthy people, equal in age and sex, were comprised as the study controls. Macula and retinal layer segmentation was performed by OCT imaging with a Spectralis OCT machine (Heidelberg Engineering, Germany).
Results: In subjects with RP, total retinal thickness was not affected in the 1 mm central area, but it was statistically significantly thinner in all four parafoveal quadrants. In subjects with Retinitis Pigmentosa, ONL, IPL, GCL and RPE were statistically significantly thinner, and OPL and INL were considerably thicker (p < 0.05).
Conclusions: In subjects with RP with foveal contour is preserved, there are non-homogeneous changes in the retinal layers and the total retinal thickness decreases in the parafoveal region.
Keywords : Retinitis pigmentosa, OCT segmentation, retinal thickness, foveal anatomy, retinal layers