2University of Health Sciences, Antalya Education and Research Hospital, Department of Ophthalmology, Antalya, Türkiye DOI : 10.37845/ret.vit.2024.33.44 Purpose: In this study, we aimed to compare blood inflammation markers, namely the neutrophil-to-lymphocyte ratio (NLR), plateletto- lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) between patients with IMT and healthy individuals.
Material and Methods: Forty-two patients with IMT and 50 healthy controls of similar age and gender without comorbidities were included in the study. Inflammation markers in the blood values of patients and controls were examined.
Results: The mean age of the patients with IMT was 60.27 ± 8.47 years, and that of the control group was 60.70 ± 10.38 years. The mean NLR, PLR, LMR, and red cell distribution width (RDW) values were 2.68 ± 0.98, 137 ± 30.30, 4.17 ± 0.98, and 13.85 ± 1.01% respectively, in the IMT group and 1.57 ± 0.32, 100.72 ± 16.78, 4.52 ± 1.29, and 12.93 ± 0.95% respectively, in the control group. In the IMT group, the NLR, PLR and RDW values were statistically significantly higher, and the LMR value statistically significantly lower compared to the control group (p < 0.001, p < 0.001, p = 0.01, p < 0.001, respectively).
Conclusion: This study is the first to compare inflammation markers in the blood values of patients with IMT and healthy controls. In this study, the patients with IMT presented with statistically significantly higher NLR, PLR, and RDW values and a statistically significantly lower LMR compared to the control group. We consider that the damage caused by inflammation and oxidative stress to Müller cells is effective in the pathogenesis of IMT.
Keywords : Idiopathic macular telangiectasia type 2, Inflammation, Lymphocyte-to-monocyte ratio, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio