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¹Celal Bayar Ünivesitesi Tıp Fakültesi Göz Hastalıkları A.D., Manisa, Arş. Gör.
²Celal Bayar Ünivesitesi Tıp Fakültesi Göz Hastalıkları A.D., Manisa, Doç. Dr. Purpose: To compare intravitreal injection of 20 mg/0.1 ml triamcinolone acetonide with 4 mg/0.1 ml with respect to efficacy and side-effects.
Materials and Methods: One eye each of 60 patients with a diagnosis of diabetic macular edema was included. Thirty patients were randomly injected with 20 mg while 30 received 4 mg of intravitreal triamcinolone. The patients were evaluated on the 2nd and 7th days and in the 1st, 2nd, and 3rd months of follow-up. Visual acuity, intraocular pressure, and complication rates were determined and compared statistically between the two groups.
Results: When compared in terms of visual acuity increase, 13 patients in the 4 mg group and 12 in the 20 mg group had an increase of at least two lines (p=0.71). Bacterial endophthalmitis was seen in one patient in the 20 mg group who had vitrectomy and an intravitreal antibiotic injection. The patient had a visual acuity of 0.9 at the 3rd month follow-up. An increase in IOP was observed in 10 patients in the 4 mg group, 5 patients were given antiglaucoma treatment, and 5 were observed without intervention. In the 20 mg group, there were 9 patients with an IOP rise (p>0.05). Four patients received medical treatment and none underwent surgery. There were no patients with cataract progression in the study group.
Discussion: Intravitreal triamcinolone injection in 20 mg or 4 mg doses did not create a significant difference with respect to visual acuity or complications. Keywords : Diabetes, macular edema, triamcinolone